Ion exchange separations in analytical chemistry (Samuelson, Olof)
نویسندگان
چکیده
منابع مشابه
Ion-exchange in Analytical Chemistry: Problems and Prospects
An analysis is made of some of the practical problems of ion-exchange chromatography. A comparison is made with gas—liquid chromatography and this leads to the suggestion that improvements can be made in the monitoring system and in the selection of eluents for specific separations. The need for a general purpose gradient elution apparatus is stressed. Some theoretical aspects of several factor...
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The separation of dilute binary mixtures of proteins by salt aided ion-exchange simulated moving bed (SMB) chromatography is optimized with respect to throughput, desorbent consumption and salt consumption. The optimal flow-rate ratios are analytically determined via an adopted "triangle theory". Azeotropic phenomena are included in this procedure. The salt concentrations in the feed and recycl...
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Ion-exchange chromatography (IEC) is a versatile separation technique for profiling the charge heterogeneity of biotherapeutic proteins, including monoclonal antibodies. Despite good resolving power and robustness, ionic-strength-based ion-exchange separations are product specific and time consuming to develop. Although salt gradients are more commonly applied, the utilization of pH gradients c...
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ژورنال
عنوان ژورنال: Journal of Chemical Education
سال: 1963
ISSN: 0021-9584,1938-1328
DOI: 10.1021/ed040pa669